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What proximal pharmacodynamic biomarkers should we measure
In a preliminary phase IIb trial enrolling well controlled diabetic patients with high cardiovascular risk, canakinumab significantly reduced CRP, IL-6 and fibrinogen [96]
New research is starting to show that this approach may be working against the body rather than with it
Several ongoing clinical trials are now evaluating: Biological aging biomarkers Physical function and frailty Vascular aging Cognitive outcomes Epigenetic aging Long-term healthspan endpoints As longevity physicians, we should remain enthusiasticbut scientifically disciplined
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